P18-06. Increased HIV-specific immunity in HIV-infected individuals vaccinated with a DNA prime, rAd5 boost regimen

Prospective and Retrospective Memory Complaints in HIV-Infected Individuals

Background and purpose: Deficits of retrospective memory (RetM) and prospective memory (ProM), which are two primary components of episodic memory, have been reported in prior studies in HIV-infected individuals. The present study aimed to further elucidate the characteristics of prospective and retrospective memory complaints in HIV-infected individuals. Materials and Methods: We recruited 50...

Humoral Mucosal and Systemic Immunity Results in Long-Term HIV-1 Neutralizing Prime-Boost Immunization Regimen in Mice Intranasal HIV-1-gp160-DNA/gp41 Peptide

A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade rAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204)

BACKGROUND The safety and immunogenicity of a vaccine regimen consisting of a 6-plasmid HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a recombinant adenovirus serotype-5 (rAd5) HIV-1 with matching inserts was evaluated in HIV-seronegative participants from South Africa, United States, Latin America and the Caribbean. METHODS 480 participants were evenly randomized to receive...

HIV-1-Specific Antibody Response and Function after DNA Prime and Recombinant Adenovirus 5 Boost HIV Vaccine in HIV-Infected Subjects

Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular immune responses; however, current research suggests both cellular and humoral responses are likely required for a successful therapeutic vaccine. Thus, we aim...

Physical activity and immunity in HIV-infected individuals.

The purpose of this study was to determine what relationship exists among physical activity levels and viral load and CD4+ cell count in HIV-infected individuals. Increased viral load is associated with disease progression and symptom severity. A convenience sample of 66 male and female subjects between the ages of 18 and 64 years of age (mean 39 +/- 8) was recruited from a hospital-based HIV/A...